Association of killer immunoglobulin-like receptor genotypes and haplotypes with acute lymphoblastic leukemia risk

• Published in: Innate immunity (London, England) Vol. 31; p. 17534259251314774
• Main Authors: Al-Tamimi, Jameel, Alomar, Suliman, Aljuaimlani, Ali, Mansour, Lamjed
• Format: Journal Article
• Language: English
• Published: United States SAGE Publications 01.01.2025; SAGE Publishing
• Subjects: Adolescent; Adult; Case-Control Studies; Child; Child, Preschool; Female; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Haplotypes; HLA-C Antigens - genetics; Humans; Killer Cells, Natural - immunology; Male; Middle Aged; Original; Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics; Precursor Cell Lymphoblastic Leukemia-Lymphoma - immunology; Receptors, KIR - genetics; Saudi Arabia; Young Adult; Saudi Arabia; Saudi Arabia; KIR genotype; Natural killer cells; acute lymphoblastic leukemia; HLA-C polymorphism

Killer immunoglobulin-like receptors (KIRs) are key molecules used by natural killer (NK) cells to interact with target cells. These receptors exhibit extensive genotypic polymorphism which has been associated with varying outcomes in immune responses against diseases. This study aimed to investigat...