Association of killer immunoglobulin-like receptor genotypes and haplotypes with acute lymphoblastic leukemia risk

• Published in: Innate immunity (London, England) Vol. 31; p. 17534259251314774
• Main Authors: Al-Tamimi, Jameel, Alomar, Suliman, Aljuaimlani, Ali, Mansour, Lamjed
• Format: Journal Article
• Language: English
• Published: United States SAGE Publications 01.01.2025; SAGE Publishing
• Subjects: Adolescent; Adult; Case-Control Studies; Child; Child, Preschool; Female; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Haplotypes; HLA-C Antigens - genetics; Humans; Killer Cells, Natural - immunology; Male; Middle Aged; Original; Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics; Precursor Cell Lymphoblastic Leukemia-Lymphoma - immunology; Receptors, KIR - genetics; Saudi Arabia; Young Adult; Saudi Arabia; Saudi Arabia; KIR genotype; Natural killer cells; acute lymphoblastic leukemia; HLA-C polymorphism
• ISSN: 1753-4259; 1753-4267; 1753-4267
• DOI: 10.1177/17534259251314774

Killer immunoglobulin-like receptors (KIRs) are key molecules used by natural killer (NK) cells to interact with target cells. These receptors exhibit extensive genotypic polymorphism which has been associated with varying outcomes in immune responses against diseases. This study aimed to investigate the relationships between genotypes and haplotypes with acute lymphoblastic leukemia (ALL) in Saudi patients. A total of 259 Saudi subjects including 145 cases of acute lymphoblastic leukemia (ALL) and 114 healthy controls living in Riyadh were genotyped for 16 genes and the two and allotypes using PCR-SSP genotyping method. A significant high frequency of the two inhibitory genes; (OR = 2.4;  < 0.0001) and (OR = 10.87;  = 0.0068) in ALL compared to healthy group was observed. In contrast, the activating gene was significantly higher in healthy controls (OR = 0.15,  < 0.0001) compared to ALL patients. Haplotype analysis shows that BX haplogroup was strongly associated with the occurrence of ALL (OR = 4.39;  < 0.0001). Further combinatory analysis of genes with their and ligands demonstrated strong statistically protective effect of the combination from ALL (OR = 0.06;  = 0.0003). This study presents strong evidence supporting the connection between certain genotypes, haplotypes, and combinations with acute ALL in the Saudi population. The heightened occurrence of inhibitory genes ( and ) and the BX haplotype in ALL patients indicates a possible involvement of these genetic variability with the dysfunctional of NK cells in the context of ALL disease.