Consummatory Successive Negative Contrast in Rats

• Published in: Bio-protocol Vol. 9; no. 7; p. e3201
• Main Authors: Jiménez-García, Ana María, Ruiz-Leyva, Leandro, Vázquez-Ágredos, Ana, Torres, Carmen, Papini, Mauricio R, Cendán, Cruz Miguel, Morón, Ignacio
• Format: Journal Article
• Language: English
• Published: United States Bio-Protocol 05.04.2019; Bio-protocol LLC
• Subjects: Biology; Methods; Pain; Addiction; Psychological pain; Rats; Reward loss; Successive negative contrast; Anxiety; Emotion; Frustration

Using animal models in addiction and pain research is pivotal to unravel new pathways and mechanisms for the treatment of these disorders. Reward devaluation through a consummatory successive negative contrast (cSNC) task has shown the ability to reduce physical pain sensitivity (hypoalgesia) and in...