Consummatory Successive Negative Contrast in Rats

Using animal models in addiction and pain research is pivotal to unravel new pathways and mechanisms for the treatment of these disorders. Reward devaluation through a consummatory successive negative contrast (cSNC) task has shown the ability to reduce physical pain sensitivity (hypoalgesia) and in...

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Bibliographic Details
Published inBio-protocol Vol. 9; no. 7; p. e3201
Main Authors Jiménez-García, Ana María, Ruiz-Leyva, Leandro, Vázquez-Ágredos, Ana, Torres, Carmen, Papini, Mauricio R, Cendán, Cruz Miguel, Morón, Ignacio
Format Journal Article
LanguageEnglish
Published United States Bio-Protocol 05.04.2019
Bio-protocol LLC
Subjects
Biology
Methods
Pain
Addiction
Psychological pain
Rats
Reward loss
Successive negative contrast
Anxiety
Emotion
Frustration
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Summary:Using animal models in addiction and pain research is pivotal to unravel new pathways and mechanisms for the treatment of these disorders. Reward devaluation through a consummatory successive negative contrast (cSNC) task has shown the ability to reduce physical pain sensitivity (hypoalgesia) and increase oral ethanol consumption in rats. The procedure is based on exposing the experimental animals to a 32% sucrose solution during several sessions (preshift sessions) followed by a devaluation to 4% sucrose during the next few sessions (postshift sessions). The cSNC effect can be monitored by comparing the experimental group to an unshifted control that had access to 4% sucrose throughout the entire experiment (preshift and postshift sessions). The cSNC phenomenon is defined by lower consumption of sucrose in the downshifted group than in the unshifted group during postshfit sessions.
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Contributed equally to this work
ISSN:2331-8325
2331-8325
DOI:10.21769/BioProtoc.3201