Pelvic lymph node histiocytosis mimicking metastatic prostatic adenocarcinoma: association with hip prostheses

Histological changes in lymph nodes simulating metastatic prostatic adenocarcinoma are reported. Lymph node frozen sections from 3 patients with prostatic cancer displayed marked histiocytosis. This tissue was subjected to histochemical, immunohistochemical and electron microscopic studies. Only 1 e...

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Bibliographic Details
Published inThe Journal of urology Vol. 154; no. 2 Pt 1; p. 470
Main Authors Bjornsson, B L, Truong, L D, Cartwright, Jr, J, Abrams, J, Rutledge, M L, Wheeler, T M
Format Journal Article
LanguageEnglish
Published United States 01.08.1995
Subjects
Adenocarcinoma - pathology
Adenocarcinoma - secondary
Diagnosis, Differential
Hip Prosthesis - adverse effects
Histiocytosis - pathology
Humans
Lymphatic Diseases - pathology
Lymphatic Metastasis
Male
Middle Aged
Prostatic Neoplasms - pathology
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Summary:Histological changes in lymph nodes simulating metastatic prostatic adenocarcinoma are reported. Lymph node frozen sections from 3 patients with prostatic cancer displayed marked histiocytosis. This tissue was subjected to histochemical, immunohistochemical and electron microscopic studies. Only 1 erroneous diagnosis of metastasis was made. All patients had hip prostheses for at least 6 years. Tissue replacing up to 80% of lymph nodes consisted of histiocytes containing large amounts of polyethylene. Hip replacement predisposes the patient to have pelvic lymph node histiocytosis mimicking metastatic adenocarcinoma. This history should be communicated to the pathologist. Polyethylene is the most important factor in the cause of post-prosthesis lymph node histiocytosis.
ISSN:0022-5347
DOI:10.1016/s0022-5347(01)67076-9