Oral HIV pre-exposure prophylaxis use among pregnant and postpartum women: results from real-world implementation in Lesotho

Lesotho has reached epidemic control, PrEP is an important component in maintaining that and in reaching the goal of eliminating mother-to-child transmission. We conducted a retrospective review of existing, routine PrEP health records in 26 health facilities in Lesotho. PrEP visit data were collect...

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Published inFrontiers in reproductive health Vol. 5; p. 1221752
Main Authors Masenyetse, Lieketseng J, Greenberg, Lauren, Samonyane, Felleng, Sekepe, Bokang, Mokone, Majoalane, Mokone, Mafusi J, Tukei, Vincent J, Beres, Laura K
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 31.07.2023
Subjects
breastfeeding
HIV
postpartum
pregnant women
PrEP
Reproductive Health
sub-Saharan Africa
sub-Saharan Africa
pregnant women
HIV
postpartum
PrEP
breastfeeding
medical records
prevention
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Summary:Lesotho has reached epidemic control, PrEP is an important component in maintaining that and in reaching the goal of eliminating mother-to-child transmission. We conducted a retrospective review of existing, routine PrEP health records in 26 health facilities in Lesotho. PrEP visit data were collected for pregnant and postpartum women screened for PrEP and/or enrolled in PrEP programs from 1 January 2019 through 30 June 2021 with follow-up data collected up to the date of data abstraction per site between October 2021 and May 2022. Poisson regression with robust variance was used to evaluate the association between patient characteristics and continuation of PrEP. Indications for starting PrEP were significantly associated with continuation in PrEP use. Women starting PrEP due to having a partner known to be living with HIV were the most likely to return for follow-up. In all age groups, the most common reason for starting PrEP was being in a serodiscordant relationship, though the proportion varies by age. As Lesotho is now in the process of optimizing PrEP use among pregnant and postpartum women, it is critical to revise data sources to capture information that will link PrEP records and ANC/PNC records and document pregnancy/postpartum status in order to better understand PrEP use and gaps in this population.
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Edited by: Dvora Joseph Davey, University of California, Los Angeles, United States
Reviewed by: Theresa Hoke, Family Health International 360, United States Eileen Ai-liang Yam, Mathematica, Inc., United States
ISSN:2673-3153
2673-3153
DOI:10.3389/frph.2023.1221752