Insulin immunoreactivity in the fetal and neonatal rat retina

The ganglion cell layer of pre- and postnatal rat retina is positive for insulin immunoreactivity. At birth the inner nuclear layer also stains for insulin. By 5 days after birth the layers characteristic of the mature retina are demonstrable. At this time the outer nuclear layer and both limiting m...

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Bibliographic Details
Published inNeuroscience letters Vol. 118; no. 1; p. 116
Main Authors Meimaridis, D G, Morse, D E, Pansky, B, Budd, G C
Format Journal Article
LanguageEnglish
Published Ireland 02.10.1990
Subjects
Animals
Animals, Newborn - metabolism
Female
Fetus - metabolism
Immunohistochemistry
Insulin - immunology
Insulin - metabolism
Pregnancy
Rats
Rats, Inbred Strains
Retina - growth & development
Retina - metabolism
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Summary:The ganglion cell layer of pre- and postnatal rat retina is positive for insulin immunoreactivity. At birth the inner nuclear layer also stains for insulin. By 5 days after birth the layers characteristic of the mature retina are demonstrable. At this time the outer nuclear layer and both limiting membranes show insulin reactivity. The lens is positive for insulin at all stages studied and the retinal pigment and choroid layers are positive after birth. These observations suggest that insulin may be important in differentiation and/or maturation of the retina.
ISSN:0304-3940
DOI:10.1016/0304-3940(90)90262-8