Delaying age at first sexual intercourse provides protection against oral cavity cancer: a mendelian randomization study
To investigate whether age at first sexual intercourse could lead to any changes in the risk of oral cavity cancer. A two-sample mendelian randomization was conducted using genetic variants associated with age at first sexual intercourse in UK biobank as instrumental variables. Summary data of North...
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Published in | Frontiers in oncology Vol. 14; p. 1361527 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
Frontiers Media S.A
18.04.2024
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Subjects | |
Online Access | Get full text |
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Summary: | To investigate whether age at first sexual intercourse could lead to any changes in the risk of oral cavity cancer.
A two-sample mendelian randomization was conducted using genetic variants associated with age at first sexual intercourse in UK biobank as instrumental variables. Summary data of Northern American from a previous genome-wide association study aimed at oral cavity cancer was served as outcome. Three analytical methods: inverse variance-weighted, mendelian randomization Egger, and weighted median were used to perform the analysis, among which inverse variance-weighted was set as the primary method. Robustness of the results was assessed through Cochran Q test, mendelian randomization Egger intercept tests, MR PRESSO, leave one out analysis and funnel plot.
The primary analysis provided substantial evidence of a positive causal relationship age at first sexual intercourse and the risk of oral cavity cancer (p = 0.0002), while a delayed age at first sexual intercourse would lead to a decreased risk of suffering oral cavity cancer (β = -1.013). The secondary outcomes confirmed the results (all β < 0) and all assessments supported the robustness, too (all
> 0.05).
The study demonstrates that a delayed sexual debut would provide protection against OCC, thus education on delaying sexual intercourse should be recommended. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Reviewed by: Ali-Farid Safi, Craniologicum - Center for Craniomaxillofacial Surgery, Switzerland These authors have contributed equally to this work Edited by: Richard Yuxiong Su, The University of Hong Kong, Hong Kong SAR, China Ata Garajei, Tehran University of Medical Sciences, Iran |
ISSN: | 2234-943X 2234-943X |
DOI: | 10.3389/fonc.2024.1361527 |