Chorangiomatosis: Evaluation of a Placental Vascular Lesion and Related Clinical Effects

• Published in: Fetal and pediatric pathology Vol. 33; no. 5-6; pp. 331 - 338
• Main Authors: Momeni Boroujeni, Amir, Yousefi, Elham, Vincent, Miriam T., Anderson, Virginia
• Format: Journal Article
• Language: English
• Published: England Informa Healthcare 01.10.2014; Taylor & Francis
• Subjects: Chorangiomatosis; Female; Hemangioma - pathology; Humans; Infant, Newborn; Placenta Diseases - pathology; Placental Vascular Lesions; Pregnancy; Pregnancy Outcome; Pregnancy Outcomes; Risk Factors; Placental Vascular Lesions; Chorangiomatosis; Pregnancy Outcomes
• ISSN: 1551-3815; 1551-3823
• DOI: 10.3109/15513815.2014.977620

Background: Chorangiomatosis is a unique placental vascular abnormality that can cause growth retardation and even fetal demise in severe cases. In this study we aim to better understand this lesion and the possible clinical implications. Methods and Materials: In this study 170 placentas were evaluated, both grossly and microscopically. The patients' charts were reviewed and relevant clinical data were extracted. In the histological examination, presence of placental lesions including chorangiomatosis (focal, multifocal and diffuse) and chorangiosis was determined and possible correlation between placental findings and clinical outcomes investigated. Results: Among the 170 placentas examined, 42 cases of multifocal chorangiomatosis (25.6%), 7 cases with diffuse chorangiomatosis (4.26%), and 56 cases of focal chorangiomatosis (34.1%) were identified. We found that there is a significant correlation between multifocal/diffuse chorangiomatosis and adverse clinical outcomes including lower birth weight and NICU admission. Conclusion: Chorangiomatosis can significantly affect the outcomes of pregnancy and more research is needed to better understand this lesion.