Atypical B Cell Receptor Signaling: Straddling Immune Diseases and Cancer

The B-cell receptor (BCR) signaling pathway plays an essential role in the survival, proliferation, differentiation and trafficking of lymphocytic. Recent findings associate aberrant BCR signaling with specific disease pathologies, including B-cell malignancies and autoimmune disorders. Inhibition o...

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Bibliographic Details
Published inInternational Reviews of Immunology Vol. 32; no. 4; pp. 355 - 357
Main Author Faris, Mary
Format Journal Article
LanguageEnglish
Published England Informa Healthcare 01.08.2013
Taylor & Francis
Subjects
Animals
Autoimmune Diseases - immunology
Autoimmune Diseases - metabolism
B-cell survival
B-lymphocyte pathogenesis
chronic lymphocytic leukemia
Humans
Leukemia, B-Cell - immunology
Leukemia, B-Cell - metabolism
Lymphoma, B-Cell - immunology
Lymphoma, B-Cell - metabolism
Receptors, Antigen, B-Cell - immunology
Receptors, Antigen, B-Cell - metabolism
Signal Transduction
systemic lupus erythematosus
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Summary:The B-cell receptor (BCR) signaling pathway plays an essential role in the survival, proliferation, differentiation and trafficking of lymphocytic. Recent findings associate aberrant BCR signaling with specific disease pathologies, including B-cell malignancies and autoimmune disorders. Inhibition of the BCR signaling pathway may therefore provide promising new strategies for the treatment of B-cell diseases. This special issue of International Reviews of Immunology focuses on atypical B-cell receptor signaling, its role in immune diseases and cancer, and its implications for potential therapeutic intervention.
Bibliography:SourceType-Other Sources-1
content type line 63
ObjectType-Editorial-2
ObjectType-Commentary-1
ISSN:0883-0185
1937-4364
1563-5244
DOI:10.3109/08830185.2013.817248