Serum chemical elements and oxidative status in Alzheimer's disease, Parkinson disease and multiple sclerosis

• Published in: Neurotoxicology (Park Forest South) Vol. 28; no. 3; pp. 450 - 456
• Main Authors: Alimonti, Alessandro, Ristori, Giovanni, Giubilei, Franco, Stazi, Maria Antonia, Pino, Anna, Visconti, Andrea, Brescianini, Sonia, Monti, Micaela Sepe, Forte, Giovanni, Stanzione, Paolo, Bocca, Beatrice, Bomboi, Giuseppe, D’Ippolito, Cristina, Annibali, Viviana, Salvetti, Marco, Sancesario, Giuseppe
• Format: Journal Article
• Language: English
• Published: Orlando, FL Elsevier B.V 01.05.2007; Elsevier
• Subjects: Adult and adolescent clinical studies; Aged; Aged, 80 and over; Alzheimer Disease - blood; Alzheimer's disease; Analysis of Variance; Biological and medical sciences; Biomarkers; Chemical elements; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Elements; Female; Forward discriminant analysis; Free Radicals - metabolism; Humans; Hydrogen Peroxide - metabolism; Male; Medical sciences; Metals - blood; Middle Aged; Multiple sclerosis; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis; Neurology; Organic mental disorders. Neuropsychology; Oxidants - blood; Oxidation-Reduction; Parkinson disease; Parkinson Disease - blood; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Serum oxidative status; Toxicology; Parkinson disease; Forward discriminant analysis; Multiple sclerosis; Serum oxidative status; Chemical elements; Alzheimer's disease; Nervous system diseases; Discriminant analysis; Alzheimer disease; Chemical compound; Cerebral disorder; Inflammatory disease; Central nervous system disease; Serum; Degenerative disease; Extrapyramidal syndrome
• ISSN: 0161-813X; 1872-9711
• DOI: 10.1016/j.neuro.2006.12.001

The role of some chemical elements in neurodegeneration was suggested by various authors. To obtain a profile of chemical elements and oxidative status in complex neurological diseases, an unbiased “omics” approach, i.e., quantification of 26 elements and oxidative stress parameters (serum oxidative status (SOS) and serum anti-oxidant capacity (SAC)), combined with multivariate statistical procedures (forward discriminant analysis, FDA) to analyse the vast amount of data, was applied to four groups of subjects (53 patients with Alzheimer's disease (AD), 71 with Parkinson disease (PD), 60 with multiple sclerosis (MS) and 124 healthy individuals). Descriptive statistics revealed numerous differences between each disease and healthy status. A concordant imbalance (reduction in Fe, Zn and SAC, and increase in SOS) was shared by AD, PD and MS. The FDA yielded three significant discriminant functions based on age, SOS, Ca, Fe, Si, Sn, V, Zn and Zr, and identified disease-specific profiles of element imbalances, thus showing the appropriateness of the “omics” approach. It may help assess the contribution of chemical elements and oxidative stress to disease causation and may provide complex predictors of disease evolution or treatment response.