An Integrated Nomogram Combining Clinical Factors and Microtubule-Associated Protein 1 Light Chain 3B Expression to Predict Postoperative Prognosis in Patients with Intrahepatic Cholangiocarcinoma

• Published in: Cancer research and treatment Vol. 52; no. 2; pp. 469 - 480
• Main Authors: Chen, Liang, Fu, Hongyuan, Lu, Tongyu, Cai, Jianye, Liu, Wei, Yao, Jia, Liang, Jinliang, Zhao, Hui, Zhang, Jiebin, Zheng, Jun, Zhang, Yingcai, Yang, Yang
• Format: Journal Article
• Language: English
• Published: Korea (South) Korean Cancer Association 01.04.2020; 대한암학회
• Subjects: Cholangiocarcinoma - genetics; Cholangiocarcinoma - surgery; Cohort Studies; Disease Progression; Female; Humans; Male; Microtubule-Associated Proteins - metabolism; Middle Aged; Nomograms; Original; Postoperative Period; Prognosis; Risk Factors; 의학일반; Prognosis; LC3B; Autophagy; Nomogram; Intrahepatic cholangiocarcinoma
• ISSN: 1598-2998; 2005-9256; 2005-9256
• DOI: 10.4143/crt.2019.423

PurposeMicrotubule-associated protein 1 light chain 3B (LC3B) serves as a key component of autophagy, which is associated with the progression of carcinoma. Yet, it is still unclear whether LC3B is also an independent risk factor for intrahepatic cholangiocarcinoma (ICC). We aim to explore the predictive value of LC3B on prognosis of ICC, and to establish a novel and available nomogram to predict relapse-free survival (RFS) and overall survival (OS) for these patients after curative-intent hepatectomy.Materials and MethodsFrom August 2004 to March 2017, 105 ICC patients were eligibly enrolled in the Third Affiliated Hospital of Sun Yat-sen University. Preoperative clinical information of enrolled patients was collected. Expression LC3B in the ICC specimen was detected by immunohistochemistry.ResultsThe 5-year RFS and OS in this cohort were 15.7% and 29.6%, respectively. On multivariate Cox regression analysis, independent risk factors for 5-year OS were cancer antigen 125, microvascular invasion, LC3B expression and lymph node metastasis. Except for the above 4 factors, neutrophil/lymphocyte ratio and tumor differentiation were independent factors for 5-year RFS. The area under the curve of nomograms for OS and RFS were 0.820 and 0.747, respectively.ConclusionThe nomograms based on LC3B can be considered as effective models to predict postoperative survival for ICC patients.