Frequency of IDH1 mutation in adult-type diffuse astrocytic gliomas in a tertiary hospital in Kenya

The 2021 WHO classification of gliomas has separated gliomas based on their IDH mutation status, reflecting differences in their pathogenesis and clinical characteristics. There is a paucity of data on the prevalence of IDH mutations in gliomas in this region. This study aimed to determine the frequ...

Full description

Saved in:
Bibliographic Details
Published inFrontiers in medicine Vol. 11; p. 1305714
Main Authors Gakinya, Samuel, Mutuiri, Anderson, Onyuma, Timothy, Cheserem, Beverly, Mogere, Edwin
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 19.02.2024
Subjects
Africa
astrocytoma
frequency
glioma
IDH1
Kenya
Medicine
glioma
astrocytoma
Kenya
IDH1
Africa
frequency
Online AccessGet full text

Cover

More Information
Summary:The 2021 WHO classification of gliomas has separated gliomas based on their IDH mutation status, reflecting differences in their pathogenesis and clinical characteristics. There is a paucity of data on the prevalence of IDH mutations in gliomas in this region. This study aimed to determine the frequency of the IDH1 mutation in adult-type diffuse astrocytic gliomas in a tertiary hospital in Kenya. Approximately half of the gliomas were positive for the IDH1 mutation, with a slight male predominance. Our study provides crucial insights into the frequency of IDH1 mutations in gliomas in Kenya.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Penelope McKelvie, St. Vincent's Hospital (Melbourne), Australia
Reviewed by: Liana Kozanno, Massachusetts General Hospital and Harvard Medical School, United States
Edited by: Aliyah Sohani, Massachusetts General Hospital and Harvard Medical School, United States
ISSN:2296-858X
2296-858X
DOI:10.3389/fmed.2024.1305714