Frequency of IDH1 mutation in adult-type diffuse astrocytic gliomas in a tertiary hospital in Kenya
The 2021 WHO classification of gliomas has separated gliomas based on their IDH mutation status, reflecting differences in their pathogenesis and clinical characteristics. There is a paucity of data on the prevalence of IDH mutations in gliomas in this region. This study aimed to determine the frequ...
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Published in | Frontiers in medicine Vol. 11; p. 1305714 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
Frontiers Media S.A
19.02.2024
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Subjects | |
Online Access | Get full text |
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Summary: | The 2021 WHO classification of gliomas has separated gliomas based on their IDH mutation status, reflecting differences in their pathogenesis and clinical characteristics. There is a paucity of data on the prevalence of IDH mutations in gliomas in this region. This study aimed to determine the frequency of the IDH1 mutation in adult-type diffuse astrocytic gliomas in a tertiary hospital in Kenya. Approximately half of the gliomas were positive for the IDH1 mutation, with a slight male predominance. Our study provides crucial insights into the frequency of IDH1 mutations in gliomas in Kenya. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Penelope McKelvie, St. Vincent's Hospital (Melbourne), Australia Reviewed by: Liana Kozanno, Massachusetts General Hospital and Harvard Medical School, United States Edited by: Aliyah Sohani, Massachusetts General Hospital and Harvard Medical School, United States |
ISSN: | 2296-858X 2296-858X |
DOI: | 10.3389/fmed.2024.1305714 |