Green biosynthesis of Pt-nanoparticles from Anbara fruits: Toxic and protective effects on CCl4 induced hepatotoxicity in Wister rats

• Published in: Arabian journal of chemistry Vol. 13; no. 2; pp. 4386 - 4403
• Main Authors: Al-Radadi, Najlaa S., Adam, Shama I.Y.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.02.2020; Elsevier
• Subjects: Aqueous Anbara extract; Biomimetic synthesis; Hepatotoxicity; Histopathology; Liver enzymes; Pt-nanoparticles; Pt-nanoparticles; Liver enzymes; Histopathology; Hepatotoxicity; Biomimetic synthesis; Aqueous Anbara extract
• ISSN: 1878-5352; 1878-5379
• DOI: 10.1016/j.arabjc.2019.08.008

[Display omitted] Platinum Nanoparticles (PtNPs) are synthesized from the Anbara fruit (Phoenix dactylifera L.) and are characterized using various spectroscopic analytical methods. These PtNPs were used to study the Hepatotoxic and Hepatoprotective effects on acute liver damage caused by CCl4 in Wister rats. Seventy-two rats of both sexes are divided into twelve groups and are treated with PtNPs and aqueous Anbara extract (AAE). Histopathological examinations were performed to identify the toxic effects on the vital organs of the rats. Hepatoprotective activity was monitored by observing the serobiochemical and hematological parameters and the intensity of hepatic marker enzymes alanine transferase (ALT), aspartate amino transferase (AST) and alkaline phosphatase (ALP) in the organs such as liver, intestine and kidney. Considerable experimental results were obtained when compared with the standard drug Silymarine. The PtNPs and AAE were proven to have protective activity of enzymes in the liver of Wister rats.