Static magnetic field attenuates lipopolysaccharide-induced multiple organ failure: A histopathologic study in mice

• Published in: International journal of radiation biology Vol. 91; no. 2; pp. 135 - 141
• Main Authors: Lai, Wei-Yi, Huang, Yu-Chih, Chang, Wei-Jen, Wang, Hsin-Ta, Fong, Tsorng-Harn, Lin, Che-Tong, Huang, Haw-Ming
• Format: Journal Article
• Language: English
• Published: England Informa Healthcare 01.02.2015; Taylor & Francis
• Subjects: Animals; histopathology; Kidney Cortex - drug effects; Kidney Cortex - pathology; lipopolysaccharide; Lipopolysaccharides - adverse effects; Liver - drug effects; Liver - pathology; Magnetic Fields; Male; Mice; Mice, Inbred BALB C; multiple organ failure; Multiple Organ Failure - chemically induced; Multiple Organ Failure - pathology; Multiple Organ Failure - therapy; Static magnetic field; histopathology; multiple organ failure; Static magnetic field; lipopolysaccharide
• ISSN: 0955-3002; 1362-3095; 1362-3095
• DOI: 10.3109/09553002.2015.959669

Abstract Purpose: Previous studies demonstrated that static magnetic fields (SMF) were effective in down-regulating the expression of lipopolysaccharide (LPS)-induced inflammatory cytokines. The aim of this study was to provide histological evidence of SMF attenuating LPS-induced multiple organ failure (MOF). Materials and methods: In this study, BALB/cByJNarl (5 weeks, weighing 20-25 g) mice were chosen as test subjects. The tested animals were challenged with 50 mg/kg LPS after they were exposed to a continuous SMF for 2 h. The survival rate and pathological changes in lungs, kidneys, and livers of the LPS- challenged mice were examined with and without SMF treatment. In addition, the effects of SMF exposure on body temperature control of the LPS-challenged mice were monitored. Results: Our results showed that at 30 h the survival rate of LPS-challenged mice increased 3.6-fold (p < 0.05). In addition, 6 h after LPS injection, the average body temperature of SMF-exposed mice was 1.07°C lower than that of unexposed animals. Tissue biopsies demonstrated that SMF exposure reduced damage to the lungs, livers, and kidneys in the LPS-challenged mice. Conclusions: SMF show potential as a viable prophylactic alternative for controlling LPS-induced MOF.