A randomized controlled trial of combination treatment with ketoconazole 2% cream and adapalene 0.1% gel in pityriasis versicolor

Abstract Background: Ketoconazole cream and adapalene gel are effective drugs against pityriasis versicolor. However, there are no reports on combination treatment with both compounds in pityriasis versicolor. Objective: To evaluate the efficacy and safety of combination therapy with adapalene 0.1%...

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Published inThe Journal of dermatological treatment Vol. 26; no. 2; pp. 143 - 146
Main Authors Shi, Tian-Wei, Zhang, Jiang-An, Tang, Yong-Bo, Yu, Hong-Xing, Li, Zhan-Guo, Yu, Jian-Bin
Format Journal Article
LanguageEnglish
Published England Informa UK Ltd 01.04.2015
Informa Healthcare
Subjects
Adapalene
Adapalene - administration & dosage
Adult
combination
Drug Therapy, Combination
Female
Humans
ketoconazole
Ketoconazole - administration & dosage
Male
pityriasis versicolor
Tinea Versicolor - drug therapy
treatment
Young Adult
treatment
ketoconazole
Adapalene
pityriasis versicolor
combination
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Summary:Abstract Background: Ketoconazole cream and adapalene gel are effective drugs against pityriasis versicolor. However, there are no reports on combination treatment with both compounds in pityriasis versicolor. Objective: To evaluate the efficacy and safety of combination therapy with adapalene 0.1% gel and ketoconazole 2% cream against pityriasis versicolor. Methods: Participants with pityriasis versicolor were randomly assigned to two groups: the combination group was treated with adapalene 0.1% gel and ketoconazole 2% cream once daily, and the monotherapy group received ketoconazole 2% cream twice daily. The treatment lasted 2 weeks in both groups. Outcomes were assessed at baseline and 1, 2 and 4 weeks after the initiation of treatment. Results: We noted clinically significant differences in total improvement rates between groups Weeks 1 and 2. A statistically significant difference was obtained Week 4. The treatment was well tolerated by all participants. Conclusions: The combination of adapalene 0.1% gel and ketoconazole 2% cream is effective and safe in the treatment of pityriasis versicolor. This therapeutic regimen was rapid, providing a valuable option for patients with pityriasis versicolor.
Bibliography:ObjectType-Article-2
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ISSN:0954-6634
1471-1753
DOI:10.3109/09546634.2014.921661