Kinetics of serotonin in platelets in essential hypertension

In a study of the kinetics of 5-hydroxytryptamine (5-HT) in platelets in 26 hypertensive subjects with a mean systolic and diastolic blood pressure of 153.9 +/- 26.9 and 106.9 +/- 9.1 mm Hg respectively, it has been observed that in hypertensive platelets there was a marked decrease in 5-HT uptake a...

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Bibliographic Details
Published inLife sciences (1973) Vol. 46; no. 5; p. 367
Main Authors Nityanand, S, Tekwani, B L, Chandra, M, Shanker, K, Singh, B N
Format Journal Article
LanguageEnglish
Published Netherlands 1990
Subjects
Blood Platelets - metabolism
Blood Pressure
Humans
Hydroxyindoleacetic Acid - blood
Hypertension - blood
Kinetics
Regression Analysis
Serotonin - blood
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Summary:In a study of the kinetics of 5-hydroxytryptamine (5-HT) in platelets in 26 hypertensive subjects with a mean systolic and diastolic blood pressure of 153.9 +/- 26.9 and 106.9 +/- 9.1 mm Hg respectively, it has been observed that in hypertensive platelets there was a marked decrease in 5-HT uptake and content, an increase in 5-HT efflux and an accompanying increase in Plasma 5-HT and 5-HIAA levels. Regression analysis of the data indicated a significant correlation between rise in diastolic blood pressure and these changes in 5-HT kinetics.
ISSN:0024-3205
DOI:10.1016/0024-3205(90)90016-K