Association of antipsychotic induced weight gain and body mass index with GNB3 gene: A meta-analysis

• Published in: Progress in neuro-psychopharmacology & biological psychiatry Vol. 32; no. 8; pp. 1848 - 1853
• Main Authors: Souza, Renan P., De Luca, Vincenzo, Muscettola, Giovanni, Rosa, Daniela V.F., de Bartolomeis, Andrea, Romano Silva, Marco, Kennedy, James L.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 12.12.2008; Elsevier
• Subjects: Antipsychotic Agents - pharmacology; Antipsychotic Agents - therapeutic use; Antipsychotic-induced weight gain; Biological and medical sciences; BMI; Body Mass Index; GNB-3; Heterotrimeric GTP-Binding Proteins - genetics; Humans; Medical sciences; Mental Disorders - drug therapy; Mental Disorders - physiopathology; Meta-analysis; Metabolic diseases; Neuropharmacology; Obesity; Pharmacogenetics; Pharmacology. Drug treatments; Polymorphism, Single Nucleotide - genetics; Psycholeptics: tranquillizer, neuroleptic; Psychology. Psychoanalysis. Psychiatry; Psychopharmacology; Weight Gain - drug effects; Weight Gain - genetics; Obesity; C; T; GNB-3; Antipsychotic-induced weight gain; BMI; Meta-analysis; Neuroleptic; Psychotropic; Toxicity; Nutrition disorder; Review; Weight gain; Metaanalysis; Body mass index; Gene; Genetics; Nutritional status
• ISSN: 0278-5846; 1878-4216
• DOI: 10.1016/j.pnpbp.2008.08.014

It has been reported that C825T variant in the gene encoding the G-protein subunit β3 (GNB3) is associated with antipsychotic-induced weight gain and obesity. We investigated the association of the GNB3 and antipsychotic-induced weight gain as well as body mass index (BMI) using meta-analytical techniques. Our analysis of 402 schizophrenia subjects showed a trend ( p = 0.072) only under a fixed-model. As it was observed heterogeneity among the studies ( p = 0.007), we re-analyzed using a random-effects framework and no significance was found ( p = 0.339). No evidence for bias publication was reported ( p = 0.868). Our analysis of 18,903 subjects showed a trend ( p = 0.053) associating CC and lower BMI under a fixed model. Although no significant association was found, the same pattern (CC and lower antipsychotic-induced weight gain) was observed. Our meta-analysis indicates that firmly establishing the role of pharmacogenetics in clinical psychiatry requires much larger sample sizes that have been reported.