Pharmacokinetics of a parenteral carbapenem, biapenem, in patients with end-stage renal disease and influence of haemodialysis

• Published in: Journal of antimicrobial chemotherapy Vol. 46; no. 5; pp. 839 - 842
• Main Authors: Nagashima, Satoru, Kozawa, Osamu, Otsuka, Takanobu, Kohno, Ken-ichi, Minamoto, Masahiko, Yokokawa, Masahiro, Kanamaru, Mitsutaka, Uematsu, Toshihiko
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.11.2000; Oxford Publishing Limited (England)
• Subjects: Adult; Anti-Infective Agents - blood; Anti-Infective Agents - pharmacokinetics; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Area Under Curve; Biological and medical sciences; Half-Life; Humans; Kidney Failure, Chronic - blood; Medical sciences; Middle Aged; Pharmacology. Drug treatments; Renal Dialysis - methods; Thienamycins - blood; Thienamycins - pharmacokinetics; Human; Urinary system disease; Intravenous administration; Hemodialysis; Toxicity; Blood; Antibiotic; Carbapenem derivatives; Chemotherapy; Treatment; Antibacterial agent; Biapenem; Pharmacokinetics
• ISSN: 0305-7453; 1460-2091; 1460-2091
• DOI: 10.1093/jac/46.5.839

The effects of haemodialysis on the pharmacokinetics of a carbapenem, biapenem, were evaluated in five patients with end-stage renal disease, who received 1 h iv infusions of 300 mg biapenem on both the days on and off 4 h haemodialysis. With haemodialysis, plasma biapenem exhibited two elimination phases, one during and the other after haemodialysis with half-lives of 1.16 ± 0.12 and 3.33 ± 0.91 h, respectively. Ninety percent of biapenem was removed from blood to dialysate. Without haemodialysis, plasma biapenem was mono-exponentially eliminated with a half-life of 4.35 ± 1.30 h.