Divergent Human Papillomavirus Type 16 Variants Are Serologically Cross-Reactive

It is not known whether DNA sequence variants of human papillomavirus type 16 (HPV-16) are distinct serotypes. To examine this question, the reactivities of women's sera from Zaire (n = 97) and Denmark (n = 123) were compared in IgG-specific ELISAs based on virus-like particles (VLPs) composed...

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Published inThe Journal of infectious diseases Vol. 172; no. 6; pp. 1584 - 1587
Main Authors Cheng, Grace, Icenogle, Joseph P., Kirnbauer, Reinhard, Hubbert, Nancy L., St. Louis, Michael E., Han, Chenglong, Svare, Edith I., Kriiger Kjaer, Susanne, Lowy, Douglas R., Schiller, John T.
Format Journal Article
LanguageEnglish
Published Chicago, IL The University of Chicago Press 01.12.1995
University of Chicago Press
Subjects
Amino acids
Biological and medical sciences
Cancer
Capsid proteins
Concise Communications
Cross Reactions
Epidemiology
Female
Fundamental and applied biological sciences. Psychology
Genitalia
Geographic regions
Human papillomavirus 16
Humans
Immunoglobulin G - immunology
Microbiology
Nucleotide sequences
Papillomaviridae - classification
Papillomaviridae - immunology
Reactivity
Virion - immunology
Virions
Virology
Viruses
Denmark
Zaire
Europe
Africa
Papillomavirus
Virus
Human
Human papillomavirus 16
Nucleotide sequence
Genetic variant
Cross reaction
Serum
Papovaviridae
Serotype
Epidemiology
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Summary:It is not known whether DNA sequence variants of human papillomavirus type 16 (HPV-16) are distinct serotypes. To examine this question, the reactivities of women's sera from Zaire (n = 97) and Denmark (n = 123) were compared in IgG-specific ELISAs based on virus-like particles (VLPs) composed of the L1 major capsid protein derived from an HPV-16 variant common in central Africa (Z-1194)or one common in northern Europe (114K). These L1s differ in seven amino acids. There was a strong correlation between reactivity in the two assays for both sets of sera (correlation coefficients, 0.73 and 0.85 for Zairian and Danish sera, respectively). In only 1 serum was there evidence for a specific reaction to one but not the other VLP variant. The results support the conclusion that the virions of strains Z-1194 and 114K are serologically cross-reactive.
Bibliography:istex:49EDB49CC7A30FEC987D1F82EA491A631CF2F8B7
Present affiliations: Massachusetts Institute of Technology, Cambridge (G.C.); Department of Dermatology, University of Vienna Medical School, Vienna, Austria (R.K.).
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Reprints or correspondence: Dr. John T. Schiller, Laboratory of Cellular Oncology, NCI, NIH, Building 36, Room 1D32, Bethesda, MD 20892.
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ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/172.6.1584