The Frustrated Gene: Origins of Eukaryotic Gene Expression

Eukarytotic gene expression is frustrated by a series of steps that are generally not observed in prokaryotes and are therefore not essential for the basic chemistry of transcription and translation. Their evolution may have been driven by the need to defend against parasitic nucleic acids.

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Bibliographic Details
Published inCell Vol. 155; no. 4; pp. 744 - 749
Main Author Madhani, Hiten D.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 07.11.2013
Subjects
Bacteria - chemistry
Bacteria - genetics
Bacteria - metabolism
Biological Evolution
Chromatin - chemistry
Chromatin - metabolism
DNA Transposable Elements
Eukaryotic Cells - chemistry
Eukaryotic Cells - physiology
Eukaryotic Cells - virology
Gene Expression
Genetic Fitness
RNA Splicing
RNA, Messenger - chemistry
RNA, Messenger - genetics
RNA, Messenger - metabolism
Viruses - genetics
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Summary:Eukarytotic gene expression is frustrated by a series of steps that are generally not observed in prokaryotes and are therefore not essential for the basic chemistry of transcription and translation. Their evolution may have been driven by the need to defend against parasitic nucleic acids.
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ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2013.10.003