Exercise Training Attenuates Obesity-Induced Skeletal Muscle Remodeling and Mitochondria-Mediated Apoptosis in the Skeletal Muscle

• Published in: International journal of environmental research and public health Vol. 15; no. 10; p. 2301
• Main Authors: Heo, Jun-Won, Yoo, Su-Zi, No, Mi-Hyun, Park, Dong-Ho, Kang, Ju-Hee, Kim, Tae-Woon, Kim, Chang-Ju, Seo, Dae-Yun, Han, Jin, Yoon, Jin-Hwan, Jung, Su-Jeen, Kwak, Hyo-Bum
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 19.10.2018; MDPI
• Subjects: Animals; Apoptosis; Apoptosis - physiology; High fat diet; Insulin resistance; Male; Mice; Mice, Inbred C57BL; Mitochondria; Mitochondria - physiology; Muscle, Skeletal - physiopathology; Muscles; Obesity; Obesity - complications; Obesity - physiopathology; Physical Conditioning, Animal; Random Allocation; Rodents; Skeletal muscle; apoptosis; exercise; skeletal muscle; mitochondria; obesity
• ISSN: 1660-4601; 1661-7827; 1660-4601
• DOI: 10.3390/ijerph15102301

Obesity is characterized by the induction of skeletal muscle remodeling and mitochondria-mediated apoptosis. Exercise has been reported as a positive regulator of skeletal muscle remodeling and apoptosis. However, the effects of exercise on skeletal muscle remodeling and mitochondria-mediated apoptosis in obese skeletal muscles have not been clearly elucidated. Four-week-old C57BL/6 mice were randomly assigned into four groups: control (CON), control plus exercise (CON + EX), high-fat diet (HFD), and HFD plus exercise groups (HFD + EX). After obesity was induced by 20 weeks of 60% HFD feeding, treadmill exercise was performed for 12 weeks. Exercise ameliorated the obesity-induced increase in extramyocyte space and a decrease in the cross-sectional area of the skeletal muscle. In addition, it protected against increases in mitochondria-mediated apoptosis in obese skeletal muscles. These results suggest that exercise as a protective intervention plays an important role in regulating skeletal muscle structure and apoptosis in obese skeletal muscles.