Cu(II) complexes of 2-(diphenylmethylene)hydrazinecarboxamide derivatives: Synthesis, characterization and antifungal activity against Fusarium oxysporum f. sp. cubense tropical race 4

The semi- and thiosemicarbazones of benzophenone derivatives (L1–L6) had been synthesized and their respective Cu(II) complexes (1–6) were obtained as precipitates by interaction with CuCl2 in ethanolic solution. All these compounds were characterized by 1H and 13C NMR, IR, UV–Vis and elemental anal...

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Published inArabian journal of chemistry Vol. 10; no. S2; pp. S3493 - S3500
Main Authors Chan, Yi Chen, Ali, Abdussalam Salhin Mohamed, Salleh, Baharuddin, Rosli, Hafizi, Quah, Ching Kheng
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.05.2017
Elsevier
Subjects
Antifungal
Benzophenone
Fusarium oxysporum f. sp. cubense tropical race 4
Thiosemicarbazone
Fusarium oxysporum f. sp. cubense tropical race 4
Antifungal
Thiosemicarbazone
Benzophenone
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Summary:The semi- and thiosemicarbazones of benzophenone derivatives (L1–L6) had been synthesized and their respective Cu(II) complexes (1–6) were obtained as precipitates by interaction with CuCl2 in ethanolic solution. All these compounds were characterized by 1H and 13C NMR, IR, UV–Vis and elemental analysis (CHN). The structures of L1 and L4 were further elucidated by X-ray crystallography. Antifungal activities of the ligands and Cu(II) complexes were carried out to ascertain their effectiveness in the inhibition of Fusarium oxysporum f. sp. cubense tropical race 4 (Foc TR4), a highly virulent pathogen against Cavendish banana in tropical region. A few of the complexes showed noteworthy inhibition on the growth of Foc TR4 with complex 6 was the most potent antifungal agent.
ISSN:1878-5352
1878-5379
DOI:10.1016/j.arabjc.2014.02.014