Association of BSG genetic polymorphisms with atherosclerotic cerebral infarction in the Han Chinese population

• Published in: International journal of neuroscience Vol. 124; no. 10; pp. 734 - 740
• Main Authors: Zhou, Juan, Song, Bingxin, Duan, Xiaomei, Long, Yuming, Lu, Jinfeng, Li, Zhibin, Zeng, Sian, Zhan, Qiong, Yuan, Mei, Yang, Qidong, Xia, Jian
• Format: Journal Article
• Language: English
• Published: England Informa Healthcare 02.10.2014; Taylor & Francis
• Subjects: Aged; Aged, 80 and over; Asian Continental Ancestry Group - ethnology; Asian Continental Ancestry Group - genetics; atherosclerosis; Basigin - genetics; BSG gene; cerebral infarction; Cerebral Infarction - etiology; Cerebral Infarction - genetics; Female; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease - genetics; Genotype; Humans; Intracranial Arteriosclerosis - complications; Intracranial Arteriosclerosis - genetics; Male; Middle Aged; Polymorphism, Single Nucleotide - genetics; single nucleotide polymorphisms; atherosclerosis; BSG gene; single nucleotide polymorphisms; cerebral infarction
• ISSN: 0020-7454; 1563-5279; 1563-5279; 1543-5245
• DOI: 10.3109/00207454.2013.877461

The Basigin (BSG, also known as CD147/extracellular matrix metalloproteinase inducer) belongs to the immunoglobulin superfamily (IgSF). It is a cellular receptor for cyclophilin A (CypA), and is originally known as tumor cell collagenase stimulatory factor (TCSF), which could abundantly expressed on the surface of tumor cells, haematopoietic, monocytes, epithelial endothelial cells and smooth muscle cells. Accumulating evidence showed that BSG played an important role in stimulating the secretion of matrix metalloproteinases (MMPs), which has been reported to be involved in the development of atherosclerosis. Since atherosclerosis is an important risk factor for atherosclerotic cerebral infarction (ACI), we speculate that BSG genetic polymorphisms may influence formation of atherosclerosis and then development of ACI. This study aimed to detect the potential association of the single nucleotide polymorphisms (SNP, −631 G > T, −318 G > C, 10141 G > A and 10826 G > A) of BSG gene in Hunan Han Chinese population with ACI. We genotyped 199 ACI patients and 188 matched healthy controls for the four BSG SNP by method of matrix-assisted laser desorption/ionization-time-offlight mass spectrometry (MALDI-TOF MS). Our results suggested that all the polymorphisms were observed in the subjects from Changsha area of Hunan Province. However, no significant difference was observed between the distribution of these SNP in cases and controls. Therefore, we speculate that BSG genetic polymorphisms might not be an important factor in the development of ACI in our Chinese Han population.