Evidence of glutamatergic deficiency in schizophrenia
Studies of amino acid release were carried out using frozen sections from brains of schizophrenics and controls. Synaptosomes were prepared via differential centrifugation in Ficoll allowing the veratridine-induced release of aspartate, glutamate, glycine, and GABA to be measured. The release of glu...
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Published in | Neuroscience letters Vol. 121; no. 1-2; p. 77 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Ireland
02.01.1991
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Subjects | |
Online Access | Get more information |
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Summary: | Studies of amino acid release were carried out using frozen sections from brains of schizophrenics and controls. Synaptosomes were prepared via differential centrifugation in Ficoll allowing the veratridine-induced release of aspartate, glutamate, glycine, and GABA to be measured. The release of glutamate and gamma-aminobutyric acid (GABA) was reduced in the synaptosomes from schizophrenics. This decrease could be reversed partially by pre-incubation of the synaptosomes with haloperidol. Additionally, the activity of glutamate decarboxylase was decreased and partially restored by haloperidol pre-incubation. These data are consistent with the hypothesis of a glutamatergic/GABAergic deficit in schizophrenia. |
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ISSN: | 0304-3940 |
DOI: | 10.1016/0304-3940(91)90653-B |