Drosophila centrocortin is dispensable for centriole duplication but contributes to centrosome separation

Centrosomes are microtubule-organizing centers that duplicate exactly once to organize the bipolar mitotic spindle required for error-free mitosis. Prior work indicated that Drosophila centrocortin (cen) is required for normal centrosome separation, although a role in centriole duplication was not c...

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Published inG3 : genes - genomes - genetics Vol. 12; no. 2
Main Authors Mehta, Dipen S, Zein-Sabatto, Hala, Ryder, Pearl V, Lee, Jina, Lerit, Dorothy A
Format Journal Article
LanguageEnglish
Published England Oxford University Press 04.02.2022
Subjects
Animals
Centrioles
Centrosome
Drosophila - genetics
Investigation
Mitosis - genetics
Spindle Apparatus
centrocortin
RNA localization
centrosome
mitosis
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Summary:Centrosomes are microtubule-organizing centers that duplicate exactly once to organize the bipolar mitotic spindle required for error-free mitosis. Prior work indicated that Drosophila centrocortin (cen) is required for normal centrosome separation, although a role in centriole duplication was not closely examined. Through time-lapse recordings of rapid syncytial divisions, we monitored centriole duplication and the kinetics of centrosome separation in control vs cen null embryos. Our data suggest that although cen is dispensable for centriole duplication, it contributes to centrosome separation.
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Dipen S. Mehta, Hala Zein-Sabatto, Pearl V. Ryder contributed equally to this work.
ISSN:2160-1836
2160-1836
DOI:10.1093/g3journal/jkab434