Missing pieces of the pituitary puzzle: participation of extra-adenohypophyseal placode-lineage cells in the adult pituitary gland

The pituitary gland is a major endocrine tissue composing of two distinct entities, the adenohypophysis (anterior pituitary, cranial placode origin) and the neurohypophysis (posterior pituitary, neural ectoderm origin), and plays important roles in maintaining vital homeostasis. This tissue is maint...

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Published inCell and tissue research Vol. 394; no. 3; pp. 487 - 496
Main Authors Kato, Yukio, Yoshida, Saishu, Kato, Takako
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer Berlin Heidelberg 01.12.2023
Springer Nature B.V
Subjects
Biomedical and Life Sciences
Biomedicine
Cells
Ectoderm
Endoderm
Homeostasis
Human Genetics
Hypothalamus
Mesenchyme
Molecular Medicine
Neural crest
Neural stem cells
Organogenesis
Physiology
Pituitary (anterior)
Pituitary (posterior)
Pituitary gland
Progenitor cells
Proteomics
Regeneration
Review
SOX2
Neural crest cell
S100β
Pituitary
Stem cell
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Summary:The pituitary gland is a major endocrine tissue composing of two distinct entities, the adenohypophysis (anterior pituitary, cranial placode origin) and the neurohypophysis (posterior pituitary, neural ectoderm origin), and plays important roles in maintaining vital homeostasis. This tissue is maintained by a slow, consistent cell-renewal system of adult stem/progenitor cells. Recent accumulating evidence shows that neural crest-, head mesenchyme-, and endoderm lineage cells invade during pituitary development and contribute to the maintenance of the adult pituitary gland. Based on these novel observations, this article discusses whether these lineage cells are involved in pituitary organogenesis, maintenance, regeneration, dysplasia, or tumors.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0302-766X
1432-0878
DOI:10.1007/s00441-023-03829-8