Design, Synthesis and Study of Antibacterial and Antitubercular Activity of Quinoline Hydrazone Hybrids

• Published in: Heterocyclic Communications Vol. 26; no. 1; pp. 137 - 147
• Main Authors: T G, Shruthi, Subramanian, Sangeetha, Eswaran, Sumesh
• Format: Journal Article
• Language: English
• Published: Berlin Walter de Gruyter GmbH 01.01.2020; De Gruyter
• Subjects: antibacterial activity; antituberculosis; Bacteria; cytotoxicity; E coli; hydrazone; Hydrazones; Organic compounds; Quinoline; Toxicity
• ISSN: 0793-0283; 2191-0197
• DOI: 10.1515/hc-2020-0109

Emerging bacterial resistance is causing widespread problems for the treatment of various infections. Therefore, the search for antimicrobials is a never-ending task. Hydrazones and quinolines possess a wide variety of biological activities. Herewith, eleven quinoline hydrazone derivatives have been designed, synthesized, characterized and evaluated for their antibacterial activity and antitubercular potential against Mtb WT H37Rv. Compounds QH-02 , QH-04 and QH-05 were found to be promising compounds with an MIC value of 4 μg/mL against Mtb WT H37Rv. Compounds QH-02 , QH-04 , QH-05 , and QH-11 were also found to be active against bacterial strains including Acinetobacter baumanii, Escherichia coli and Staphylococcus aureus . Further, we have carried out experiments to confirm the cytotoxicity of the active compounds and found them to be non-toxic.