Ovariectomy Causes Overexpression of Renal Na+,K+-ATPase and Sodium-Sensitive Hypertension in Adult Wistar Rats

• Published in: Clinical and experimental hypertension (1993) Vol. 35; no. 7; pp. 475 - 483
• Main Authors: Di Ciano, Luis A, Azurmendi, Pablo J, Toledo, Jorge E, Oddo, Elisabet M, Zotta, Elsa, Ochoa, Federico, Arrizurieta, Elvira E, Ibarra, Fernando R.
• Format: Journal Article
• Language: English
• Published: England Informa Healthcare 01.01.2013; Taylor & Francis
• Subjects: Animals; ATPase; Blood Pressure; Female; female hormones; Hypertension - enzymology; Hypertension - etiology; Hypertension - physiopathology; Kidney - enzymology; Loop of Henle - enzymology; mTAL; Natriuresis; ovariectomy; Ovariectomy - adverse effects; Ovary - physiology; phospho state; Rats; Rats, Wistar; renal Na; Renal Plasma Flow; sodium excretion; Sodium, Dietary - administration & dosage; Sodium-Potassium-Exchanging ATPase - metabolism; sodium-sensitive hypertension
• ISSN: 1064-1963; 1525-6006
• DOI: 10.3109/10641963.2012.758273

We investigated the effect of ovariectomy(oVx) on renal and systemic hemodynamic, electrolyte excretion and total and dephosphorylated Na+,K+-ATPase α1 subunit (t-d-NKA) in normotensive Wistar rats under a normal sodium (NS, 0.24%) or high sodium (HS, 1%) intake versus intact female (IF). On NS intake, t-d-NKA was higher in oVx rats and overexpressed in the thick ascending limbs (P < .01 vs. IF) and renal plasma flow was increased. On HS intake, oVx rats maintained a greater dephosphorylated NKA, excreted less sodium, and developed arterial hypertension (134 ± 4 vs. IF 112 ± 5 mm Hg, P < .05). Sodium load caused salt-sensitive hypertension in oVx Wistar rats.