A Stay of Execution: Type I Interferons Pardon T Cells from Death by Natural Killers

In this issue of Immunity, Crouse et al., (2014) and Xu et al., (2014), show that by modulating the expression of natural killer (NK) cell receptor ligands, type I interferons protect responding T cells against culling by NK cells.

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Bibliographic Details
Published inImmunity (Cambridge, Mass.) Vol. 40; no. 6; pp. 861 - 862
Main Authors Kahan, Shannon M., Zajac, Allan J.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 19.06.2014
Elsevier Limited
Subjects
Animals
Antigens
Antigens, Ly - immunology
CD8-Positive T-Lymphocytes - immunology
Cytotoxicity, Immunologic
Immune system
Infections
Interferon Type I - immunology
Killer Cells, Natural - immunology
Ligands
Lymphocytes
Lymphocytic Choriomeningitis - immunology
Natural Cytotoxicity Triggering Receptor 1 - immunology
Receptor, Interferon alpha-beta - genetics
Receptor, Interferon alpha-beta - immunology
Viral infections
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Summary:In this issue of Immunity, Crouse et al., (2014) and Xu et al., (2014), show that by modulating the expression of natural killer (NK) cell receptor ligands, type I interferons protect responding T cells against culling by NK cells.
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ISSN:1074-7613
1097-4180
DOI:10.1016/j.immuni.2014.05.009