Efficient synthesis of enantiopure 1,2-bis(hydroxymethyl)-3,3-difluorocyclopropane derivatives through lipase-catalyzed reaction

Efficient synthesis of chiral difluorocyclopropane building block has been accomplished; prochiral diacetate of 1,2-bis(hydroxymethyl)-3, 3-difluorocyclopropane was converted to the corresponding monoacetate through Alcaligenes sp. lipase-catalyzed hydrolysis with >99% enantiomeric excess.

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Bibliographic Details
Published inChemistry letters no. 9; pp. 903 - 904
Main Authors Itoh, T, Mitsukura, K, Furutani, M
Format Journal Article
LanguageEnglish
Published TOKYO Chemical Soc Japan 01.09.1998
Subjects
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
ORGANOFLUORINE COMPOUNDS
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Summary:Efficient synthesis of chiral difluorocyclopropane building block has been accomplished; prochiral diacetate of 1,2-bis(hydroxymethyl)-3, 3-difluorocyclopropane was converted to the corresponding monoacetate through Alcaligenes sp. lipase-catalyzed hydrolysis with >99% enantiomeric excess.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.1998.903