Oncologic, Perioperative Outcomes of Female Radical Cystectomy: Results from a Multicenter Study in Korea

• Published in: Cancer research and treatment Vol. 51; no. 3; pp. 1064 - 1072
• Main Authors: Shim, Ji Sung, Seo, Ho Kyung, Ku, Ja Hyeon, Jeong, Byong Chang, Hong, Bumsik, Kang, Seok Ho
• Format: Journal Article
• Language: English
• Published: Korea (South) Korean Cancer Association 01.07.2019; 대한암학회
• Subjects: Aged; Carcinoma, Transitional Cell - surgery; Cystectomy - methods; Disease-Free Survival; Female; Humans; Kaplan-Meier Estimate; Middle Aged; Organ Sparing Treatments; Original; Retrospective Studies; Robotic Surgical Procedures; Urinary Bladder Neoplasms - surgery; 의약학; Female; Cystectomy; Urinary bladder neoplasms
• ISSN: 1598-2998; 2005-9256; 2005-9256
• DOI: 10.4143/crt.2018.515

The lower incidence of bladder cancer among women has led to a lack of information on female radical cystectomy (RC). This study aimed to analyze the characteristics related with female RC in a cohort from multiple academic institutions. This was a retrospective review of 384 female patients who underwent RC for bladder cancer. Epidemiologic, perioperative variables including urologic referral periodwith consequent pathologic stage distributions were assessed. The changes in surgical techniques over time were illustrated. Also, we evaluated recurrence-free survival (RFS) at 2 and 5 years and overall survival (OS) at 5 years with stage-specific analyses using the Kaplan-Meier method. The mean follow-up time was 35 months (interquartile rage [IQR], 9 to 55). The average time to urologic referral with initial symptoms was 5.5 (IQR, 1 to 6) months and over 20% of patients visited clinics after 6 months. In subsequent stage distributions according to referral period, T2 or higher stage distributions were abruptly increased after 1 year. Overall 2-year/5-year RFS rates were 0.72/0.57 and 5-year OS was 0.61. Notable surgical descriptions were as follows: 91% of patients underwent open RC; 80% of patients underwent an ileal conduit; and 83% of patients received anterior exenteration. However, the proportions of robotic surgery, orthotopic neobladder and organ sparing cystectomy have increased recen-tly. We identified the general characteristics and changes in pattern of female RC. Our results also suggest that women are susceptible to delays in referral to an urologist and are at greater risk for worse prognosis.