Pandrug-resistant Acinetobacter baumannii causing nosocomial infections in a university hospital, Taiwan

The rapid emergence (from 0% before 1998 to 6.5% in 2000) of pandrug-resistant Acinetobacter baumannii (PDRAB) was noted in a university hospital in Taiwan. To understand the epidemiology of these isolates, we studied 203 PDRAB isolates, taken from January 1999 to April 2000: 199 from 73 hospitalize...

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Published inEmerging infectious diseases Vol. 8; no. 8; pp. 827 - 832
Main Authors Hsueh, Po-Ren, Teng, Lee-Jene, Chen, Cheng-Yi, Chen, Wen-Hwei, Yu, Chong-Jen, Ho, Shen-Wu, Luh, Kwen-Tay
Format Journal Article
LanguageEnglish
Published United States U.S. National Center for Infectious Diseases 01.08.2002
Subjects
Acinetobacter - drug effects
Acinetobacter - genetics
Acinetobacter Infections - drug therapy
Acinetobacter Infections - microbiology
Analysis
Anti-Bacterial Agents - pharmacology
Carrier State - microbiology
Cross infection
Cross Infection - drug therapy
Cross Infection - microbiology
Disease Outbreaks
Drug resistance in microorganisms
Drug Resistance, Multiple, Bacterial
Drug Synergism
Electrophoresis, Gel, Pulsed-Field
Female
Genes, Bacterial - genetics
Genetic aspects
Genotype
Humans
Male
Microbial Sensitivity Tests
Nosocomial infections
Observational studies
Polymerase Chain Reaction
Taiwan
Taiwan
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Summary:The rapid emergence (from 0% before 1998 to 6.5% in 2000) of pandrug-resistant Acinetobacter baumannii (PDRAB) was noted in a university hospital in Taiwan. To understand the epidemiology of these isolates, we studied 203 PDRAB isolates, taken from January 1999 to April 2000: 199 from 73 hospitalized patients treated at different clinical settings in the hospital and 4 from environmental sites in an intensive-care unit. Pulsed-field gel electrophoresis analysis and random amplified polymorphic DNA (RAPD) generated by arbitrarily primed polymerase chain reaction of these 203 isolates showed 10 closely related genotypes (10 clones). One (clone 5), belonging to pulsotype E and RAPD pattern 5, predominated (64 isolates, mostly from patients in intensive care). Increasing use of carbapenems and ciprofloxacin (selective pressure) as well as clonal dissemination might have contributed to the wide spread of PDRAB in this hospital.
Bibliography:ObjectType-Article-2
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ISSN:1080-6040
1080-6059
DOI:10.3201/eid0805.020014