GLP-1–Receptor Scanning for Imaging of Human Beta Cells Transplanted in Muscle

To the Editor: Cell therapy is emerging as a realistic treatment for type 1 diabetes, on the basis of the prolonged success of intraportal islet transplantation in selected patients. 1 Key improvements include the development of alternative implantation sites and new tools for in vivo detection of t...

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Bibliographic Details
Published inThe New England journal of medicine Vol. 363; no. 13; pp. 1289 - 1290
Main Authors Pattou, Francois, Wild, Damian, Kerr-Conte, Julie
Format Journal Article
LanguageEnglish
Published United States Massachusetts Medical Society 23.09.2010
Subjects
Female
Glucagon-Like Peptide-1 Receptor
Humans
Insulin
Insulin-Secreting Cells - diagnostic imaging
Insulin-Secreting Cells - transplantation
Insulinoma - surgery
Medical imaging
Middle Aged
Muscle, Skeletal - chemistry
Muscle, Skeletal - diagnostic imaging
Organometallic Compounds
Pancreatic Neoplasms - surgery
Peptides
Radioligand Assay
Radionuclide Imaging
Receptors, Glucagon - analysis
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Summary:To the Editor: Cell therapy is emerging as a realistic treatment for type 1 diabetes, on the basis of the prolonged success of intraportal islet transplantation in selected patients. 1 Key improvements include the development of alternative implantation sites and new tools for in vivo detection of transplanted cells. In the absence of reliable beta-cell markers, previous clinical attempts to visualize transplanted islets have relied on magnetic resonance imaging 2 and positron-emission tomography. 3 However, these techniques necessitate the in vitro manipulation of islets and are limited by the short half-life of available labeling agents. Glucagon-like peptide 1 (GLP-1)–receptor scanning has been successfully . . .
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJMc1004547