Chemo-selective Synthesis of [indoline-3,4'-isoxazolo[5,4-b]pyridine Fused spirooxindole Derivatives via Brønsted Acid Catalysed Three–Component Tandem Knoevenagel/Michael Addition Reaction

With their exceptional three-dimensional structural topographies, spirooxindoles are known best for privileged chemotypes for diverse biological applications. We report herin a highly convergent and efficient protocol, for the facile chemoselective synthesis of a library of [indoline-3,4′-isoxazolo[...

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Bibliographic Details
Published inResults in Chemistry Vol. 2; p. 100064
Main Authors Boruah, Dhruba Jyoti, Maurya, Ram Awatar, Yuvaraj, Panneerselvam
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.01.2020
Elsevier
Subjects
Bronsted acid catalysed
Chemo-selective
Eco-friendly
Spirooxindole
Tandem reaction
Spirooxindole
Tandem reaction
Bronsted acid catalysed
Chemo-selective
Eco-friendly
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Summary:With their exceptional three-dimensional structural topographies, spirooxindoles are known best for privileged chemotypes for diverse biological applications. We report herin a highly convergent and efficient protocol, for the facile chemoselective synthesis of a library of [indoline-3,4′-isoxazolo[5,4-b]pyridine fused spirooxindole derivatives, has been achieved by a Brønsted acid catalyzed three component tandem Knoevenagel/Michael addition. Interestingly, the method not only offers the benefits of operational simplicity, but also chemoselective and atom economic with excellent yields of the targeted molecule. The reaction mechanism and substrate scope of this novel reaction has been thoroughly out lined. [Display omitted]
ISSN:2211-7156
2211-7156
DOI:10.1016/j.rechem.2020.100064