Ecological and Epidemiological Findings Associated with Zoonotic Rabies Outbreaks and Control in Moshi, Tanzania, 2017-2018

• Published in: International journal of environmental research and public health Vol. 16; no. 16; p. 2816
• Main Authors: Mtui-Malamsha, Niwael, Sallu, Raphael, Mahiti, Gladys R, Mohamed, Hussein, OleNeselle, Moses, Rubegwa, Bachana, Swai, Emmanuel S, Makungu, Selemani, Otieno, Edward G, Lupindu, Athuman M, Komba, Erick, Mdegela, Robinson, Assenga, Justine A, Bernard, Jubilate, Marandu, Walter, Warioba, James, Makondo, Zacharia, Chang'a, Jelly, Mramba, Furaha, Nonga, Hezron, Killewo, Japhet, Kafeero, Fred, Makonnen, Yilma J, Rivas, Ariel L, Fasina, Folorunso O
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 07.08.2019; MDPI
• Subjects: Adolescent; Adult; Aged; Animal bites; Animals; Bites; Cats; Data collection; Disease Susceptibility - epidemiology; Disease Susceptibility - veterinary; Disease transmission; Divisions; Dog Diseases - epidemiology; Dog Diseases - prevention & control; Dog Diseases - transmission; Dogs; Epidemiology; Female; Health Knowledge, Attitudes, Practice; Health risks; Humans; Immunization; Infections; Laboratories; Livestock; Male; Medical research; Middle Aged; Occupational exposure; Ownership; Public health; Questionnaires; Rabies; Rabies - epidemiology; Rabies - prevention & control; Rabies - transmission; Rabies - veterinary; Risk analysis; Risk Factors; Saliva; Sample size; Seroepidemiologic Studies; Studies; Surveillance; Tanzania - epidemiology; Towns; Vaccination; Variables; Veterinary surgeons; Viruses; Young Adult; Zoonoses; Tanzania; United States > US; Africa; rabies; rural community; human-animal interaction; zoonosis; One Health; wildlife
• ISSN: 1660-4601; 1661-7827; 1660-4601
• DOI: 10.3390/ijerph16162816

Approximately 1500 people die annually due to rabies in the United Republic of Tanzania. Moshi, in the Kilimanjaro Region, reported sporadic cases of human rabies between 2017 and 2018. In response and following a One Health approach, we implemented surveillance, monitoring, as well as a mass vaccinations of domestic pets concurrently in >150 villages, achieving a 74.5% vaccination coverage ( = 29, 885 dogs and cats) by September 2018. As of April 2019, no single human or animal case has been recorded. We have observed a disparity between awareness and knowledge levels of community members on rabies epidemiology. Self-adherence to protective rabies vaccination in animals was poor due to the challenges of costs and distances to vaccination centers, among others. Incidence of dog bites was high and only a fraction (65%) of dog bite victims (humans) received post-exposure prophylaxis. A high proportion of unvaccinated dogs and cats and the relative intense interactions with wild dog species at interfaces were the risk factors for seropositivity to rabies virus infection in dogs. A percentage of the previously vaccinated dogs remained unimmunized and some unvaccinated dogs were seropositive. Evidence of community engagement and multi-coordinated implementation of One Health in Moshi serves as an example of best practice in tackling zoonotic diseases using multi-level government efforts. The district-level establishment of the One Health rapid response team (OHRRT), implementation of a carefully structured routine vaccination campaign, improved health education, and the implementation of barriers between domestic animals and wildlife at the interfaces are necessary to reduce the burden of rabies in Moshi and communities with similar profiles.