High-dose chemotherapy and autologous CD34-positive blood stem cell transplantation for multiple myeloma in an HIV carrier

• Published in: Bone marrow transplantation (Basingstoke) Vol. 29; no. 3; pp. 273 - 275
• Main Authors: KENTOS, A, VEKEMANS, M, VAN VOOREN, J. P, LAMBERMONT, M, LIESNARD, C, FEREMANS, W, FARBER, C. M
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing Group 01.02.2002
• Subjects: Acquired Immunodeficiency Syndrome - complications; Acquired Immunodeficiency Syndrome - therapy; Adult; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Antigens, CD34 - blood; Antineoplastic Combined Chemotherapy Protocols - administration & dosage; Autografts; Biological and medical sciences; Bone marrow; Bone marrow transplantation; Bone marrow, stem cells transplantation. Graft versus host reaction; CD34 antigen; Chemotherapy; Epidemiology; Fatal Outcome; Hematopoietic Stem Cell Transplantation - methods; Hematopoietic stem cells; HIV; Human immunodeficiency virus; Humans; Immunodeficiencies. Immunoglobulinopathies; Immunoglobulinopathies; Immunopathology; Medical sciences; Multiple myeloma; Multiple Myeloma - therapy; Multiple Myeloma - virology; Patients; Stem cell transplantation; Stem cells; Transfusions. Complications. Transfusion reactions. Cell and gene therapy; Transplantation; Transplantation, Autologous; Antineoplastic agent; Human; Immunopathology; Stem cell; Retroviridae; Hematopoietic cell; AIDS; Malignant hemopathy; Myeloma; Immune deficiency; Lentivirus; Infection; Virus; Case study; Concomitant disease; Autograft; Chemotherapy; Treatment; Immunoglobulinopathy; Lymphoproliferative syndrome; Viral disease; Graft; Myelosuppression; Human immunodeficiency virus
• ISSN: 0268-3369; 1476-5365
• DOI: 10.1038/sj.bmt.1703348

The epidemiology and clinical outcome of multiple myeloma in human immunodeficiency virus (HIV)-positive patients is poorly documented. There are uncertainties concerning the optimal management of this rare disorder. We report on the use of myeloablative chemotherapy with autologous stem cell transplantation in an HIV-positive patient with multiple myeloma.