Boswellic acid captivated hydroxyapatite carboxymethyl cellulose composites for the enhancement of chondrocytes in cartilage repair

• Published in: Arabian journal of chemistry Vol. 13; no. 6; pp. 5605 - 5613
• Main Authors: Bi, Dianhai, Chen, Gang, Cheng, Jinhui, Wen, Jiabin, Pei, Na, Zeng, Huangao, Li, Yuxu
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.06.2020; Elsevier
• Subjects: Boswellic acid; Cartilage; Chondrocyte; Hydroxyapatite; Osteoarthritis; Cartilage; Hydroxyapatite; Chondrocyte; Osteoarthritis; Boswellic acid
• ISSN: 1878-5352; 1878-5379
• DOI: 10.1016/j.arabjc.2020.03.030

Recently tissue repairing bone grafted materials have been greater properties than the recapitulating intramembranous regeneration of natural bone especially cartilage damage regeneration. In this present work was designed and developed for the enhancement of chondrocyte generation for cartilage repair. Boswellic acid (BA) is a traditional compound used for the treatment of osteoarthritis. Boswellic acid subjected to involve the preparation of hydroxyapatite (HAP) and HAP-BA compounds were functionalized with carboxymethyl cellulose (CMC) to promote the extra-cellular matrix. HAP, HAP-BA and HAP-BA-CMC composites were characterized via their physicochemical properties through FTIR, XRD, SEM and TEM techniques. The antibacterial activity and chondrocyte cell variability were tested. At 14 days, HAP-BA-CMC composite was observed 67% of cell viability. The chondrocyte cell adhesion on the HAP-BA-CMC composite was investigated and it observed polygonal filopodia. From the results suggest that HAP-BA-CMC composite can improve the chondrocyte production for repair of damaged cartilage.