Angiotensin II receptor subtypes in the rat brain

The non-peptide angiotensin II (AII) receptor subtype selective antagonist, DuP 753, was used to characterize AII receptor binding sites in the rat brain. DuP 753 competed for specific 125I-[Sar1,Ile8]AII (125I-SIAII) binding in many brain nuclei (IC50 = 20-30 nM), but was a weak competitor at remai...

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Bibliographic Details
Published inEuropean journal of pharmacology Vol. 186; no. 2-3; p. 339
Main Authors Rowe, B P, Grove, K L, Saylor, D L, Speth, R C
Format Journal Article
LanguageEnglish
Published Netherlands 21.09.1990
Subjects
1-Sarcosine-8-Isoleucine Angiotensin II - pharmacology
Angiotensin II - metabolism
Animals
Autoradiography
Brain - anatomy & histology
Brain - metabolism
Imidazoles - pharmacology
Iodine Radioisotopes
Losartan
Rats
Receptors, Angiotensin - classification
Receptors, Angiotensin - metabolism
Tetrazoles - pharmacology
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Summary:The non-peptide angiotensin II (AII) receptor subtype selective antagonist, DuP 753, was used to characterize AII receptor binding sites in the rat brain. DuP 753 competed for specific 125I-[Sar1,Ile8]AII (125I-SIAII) binding in many brain nuclei (IC50 = 20-30 nM), but was a weak competitor at remaining sites (IC50 greater than 10(-4) M). DuP 753 sensitive binding sites (designated AII alpha subtype) correspond with areas where binding is inhibited by sulfhydryl reducing agents, whereas DuP 753 insensitive sites (AII beta) correspond with areas where binding is not inhibited by sulfhydryl reducing agents.
ISSN:0014-2999
DOI:10.1016/0014-2999(90)90457-H