Passive protection against infectious bursal disease virus by viral VP2 expressed in yeast

Infectious bursal disease virus (IBDV), a pathogen of major economic importance to the world's poultry industries, causes a severe immunodepressive disease in young chickens. Maternal antibodies are able to protect the progeny passively from IBDV infection. The gene encoding the IBDV host-prote...

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Bibliographic Details
Published inVaccine Vol. 8; no. 6; pp. 549 - 552
Main Authors Macreadie, Ian G., Vaughan, Paul R., Chapman, Anthony J., McKern, Neil M., Jagadish, Mittur N., Heine, Hans-G., Ward, Colin W., Fahey, Kevin J., Azad, Ahmed A.
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 01.12.1990
Elsevier
Subjects
Amino Acid Sequence
Animals
Antibodies, Monoclonal - immunology
Antibody Formation - immunology
Antigens, Viral - genetics
Antigens, Viral - immunology
Base Sequence
Biological and medical sciences
Chickens
Enzyme-Linked Immunosorbent Assay
Fundamental and applied biological sciences. Psychology
Gene Expression
Genetics
IBDV VP2
Immune Sera - immunology
Immunization, Passive
Infectious bursal disease virus - immunology
Microbiology
Molecular Sequence Data
passive protection
recombinant subunit vaccine
Saccharomyces cerevisiae
Saccharomyces cerevisiae - genetics
Virology
Yeast expression
passive protection
recombinant subunit vaccine
IBDV VP2
Yeast expression
Immunization
Yeast
Immune response
Antibody
Birnaviridae
Gene expression
Virus
Antigen
Vertebrata
Neutralization test
Gene
Birnavirus
Infectious bursal disease virus
Immunoblotting assay
Chicken
Aves
Molecular cloning
Passive immunization
ELISA assay
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Summary:Infectious bursal disease virus (IBDV), a pathogen of major economic importance to the world's poultry industries, causes a severe immunodepressive disease in young chickens. Maternal antibodies are able to protect the progeny passively from IBDV infection. The gene encoding the IBDV host-protective antigen (VP2) has been cloned and expressed in yeast resulting in the production of an antigen that very closely resembles native VP2. When injected into specific pathogen free chickens a single dose of microgram quantities of the yeast derived antigen induces high titres of virus neutralizing antibodies that are capable of passively protecting young chickens from infection with IBDV.
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ISSN:0264-410X
1873-2518
DOI:10.1016/0264-410X(90)90006-8