Cytotoxic and antimicrobial activities of some novel heterocycles employing 6-(1,3-diphenyl-1 H -pyrazol-4-yl)-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile

• Published in: Heterocyclic Communications Vol. 25; no. 1; pp. 107 - 115
• Main Authors: Ramadan, Sayed K, El-Helw, Eman A E, Sallam, Hanan A
• Format: Journal Article
• Language: English
• Published: Berlin Walter de Gruyter GmbH 28.11.2019; De Gruyter
• Subjects: Anticancer properties; Antiinfectives and antibacterials; Antimicrobial agents; antitumor and antimicrobial activity; carbon electrophiles; Nucleophiles; Synthesis; tetrahydropyrimidine; thiation; thiazolopyrimidine

A pyrimidinethione derivative namely, 6-(1,3-diphenyl-1 H -pyrazol-4-yl)-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile, was readily synthesized and reacted with carbon electrophiles in an attempt to synthesize selected fused heterocycles. The reactivity of 6-(1,3-diphenyl-1 H -pyrazol-4...