Cytotoxic and antimicrobial activities of some novel heterocycles employing 6-(1,3-diphenyl-1 H -pyrazol-4-yl)-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile

A pyrimidinethione derivative namely, 6-(1,3-diphenyl-1 H -pyrazol-4-yl)-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile, was readily synthesized and reacted with carbon electrophiles in an attempt to synthesize selected fused heterocycles. The reactivity of 6-(1,3-diphenyl-1 H -pyrazol-4...

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Published inHeterocyclic Communications Vol. 25; no. 1; pp. 107 - 115
Main Authors Ramadan, Sayed K, El-Helw, Eman A E, Sallam, Hanan A
Format Journal Article
LanguageEnglish
Published Berlin Walter de Gruyter GmbH 28.11.2019
De Gruyter
Subjects
Anticancer properties
Antiinfectives and antibacterials
Antimicrobial agents
antitumor and antimicrobial activity
carbon electrophiles
Nucleophiles
Synthesis
tetrahydropyrimidine
thiation
thiazolopyrimidine
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Summary:A pyrimidinethione derivative namely, 6-(1,3-diphenyl-1 H -pyrazol-4-yl)-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile, was readily synthesized and reacted with carbon electrophiles in an attempt to synthesize selected fused heterocycles. The reactivity of 6-(1,3-diphenyl-1 H -pyrazol-4-yl)-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile was investigated towards selected nitrogen nucleophiles. Thiation and hydrolysis reactions of the tetrahydropyrimidine derivative were investigated. Antitumor and antimicrobial activity evaluation of some of the synthesized products exhibited promising results.
Bibliography:ObjectType-Article-1
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ISSN:0793-0283
2191-0197
DOI:10.1515/hc-2019-0008