Preeclampsia is an independent risk factor for spontaneous intestinal perforation in very preterm infants

• Published in: The journal of maternal-fetal & neonatal medicine Vol. 27; no. 12; p. 1248
• Main Authors: Yılmaz, Yavuz, Kutman, H Gözde Kanmaz, Ulu, Hülya Özkan, Canpolat, F Emre, Uraş, Nurdan, Oğuz, S Suna, Dilmen, Ugur
• Format: Journal Article
• Language: English
• Published: England 01.08.2014
• Subjects: Adult; Case-Control Studies; Female; Humans; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases - epidemiology; Infant, Premature, Diseases - etiology; Infant, Very Low Birth Weight; Intestinal Perforation - epidemiology; Intestinal Perforation - etiology; Male; Pre-Eclampsia - epidemiology; Pregnancy; Retrospective Studies; Risk Factors; Rupture, Spontaneous - epidemiology; Rupture, Spontaneous - etiology; Antenatal steroids; intrauterin growth retardation; spontaneous intestinal perforation; prematurity; preeclampsia
• ISSN: 1476-4954
• DOI: 10.3109/14767058.2013.851189

Spontaneous intestinal perforation (SIP) is an important surgical emergency in preterm infants. To evaluate the effect of maternal preeclampsia on development of SIP in premature infants. Retrospective observational study in a large tertiary neonatal intensive care unit. The preterm infants of ≤32 weeks of gestational age and birthweight ≤1500 g who were hospitalized were enrolled. The primary outcome was to determine the association between preeclampsia and SIP. A total of 22 infants had SIP diagnosis. The incidence of SIP in infants born to preeclamptic mothers (6.2%) was significantly higher compared with those born to normotensive mothers (0.2%). In multinominal logistic regression model, preeclampsia was found to be an independent risk factor of SIP with an odds ratio of 13.5 (95% confidence interval 2.82-65.1). Maternal preeclampsia seemed to be an independent risk factor for development of SIP in premature infants.