Lipoic acid and lipoic acid analogs in cancer metabolism and chemotherapy

• Published in: Expert review of clinical pharmacology Vol. 7; no. 6; p. 837
• Main Authors: Bingham, Paul M, Stuart, Shawn D, Zachar, Zuzana
• Format: Journal Article
• Language: English
• Published: England 01.11.2014
• Subjects: Animals; Antineoplastic Agents - pharmacology; Citric Acid Cycle - physiology; Humans; Mitochondria - metabolism; Neoplasms - drug therapy; Neoplasms - metabolism; Thioctic Acid - analogs & derivatives; Thioctic Acid - metabolism; cancer metabolism; lipoic acid analogs; tumor mitochondria; lipoate analogs; lipoate; lipoic acid; two compartment metabolism; chemotherapy

The lipoic acid (lipoate) coenzyme is unique in all of mammalian metabolism. It is not only crucial to the function of some of the major enzymes feeding carbon into the tricarboxylic acid cycle, but also generates dynamic regulatory information about the metabolic status of the mitochondrial matrix,...