Lipoic acid and lipoic acid analogs in cancer metabolism and chemotherapy

The lipoic acid (lipoate) coenzyme is unique in all of mammalian metabolism. It is not only crucial to the function of some of the major enzymes feeding carbon into the tricarboxylic acid cycle, but also generates dynamic regulatory information about the metabolic status of the mitochondrial matrix,...

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Bibliographic Details
Published inExpert review of clinical pharmacology Vol. 7; no. 6; p. 837
Main Authors Bingham, Paul M, Stuart, Shawn D, Zachar, Zuzana
Format Journal Article
LanguageEnglish
Published England 01.11.2014
Subjects
Animals
Antineoplastic Agents - pharmacology
Citric Acid Cycle - physiology
Humans
Mitochondria - metabolism
Neoplasms - drug therapy
Neoplasms - metabolism
Thioctic Acid - analogs & derivatives
Thioctic Acid - metabolism
cancer metabolism
lipoic acid analogs
tumor mitochondria
lipoate analogs
lipoate
lipoic acid
two compartment metabolism
chemotherapy
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Summary:The lipoic acid (lipoate) coenzyme is unique in all of mammalian metabolism. It is not only crucial to the function of some of the major enzymes feeding carbon into the tricarboxylic acid cycle, but also generates dynamic regulatory information about the metabolic status of the mitochondrial matrix, ultimately functioning to control these metabolic fluxes. Moreover, these lipoate-sensitive regulatory processes are apparently systematically redesigned in tumor cells and the affected enzymes commonly become especially central to cancer metabolism. Thus, lipoate-sensitive regulatory processes constitute potentially uniquely valuable targets for chemotherapeutic attack. Our goal here is to review the current status of our knowledge relevant to the use of lipoate and lipoate analogs to therapeutically attack malignant disease.
ISSN:1751-2441
DOI:10.1586/17512433.2014.966816