Synthesis and evaluation of variably substituted N-methyl tetrahydroisoquinolines and benzazepines as monoamine reuptake inhibitors

[Display omitted] The use of N-methyl-1, 2, 3, 4-tetrahydroisoquinoline as pharmacophores has been studied over the years. It has a structural similarity with the N, N-dimethyl phenethylamine, a framework entrenched in the drug venlafaxine, acknowledged for its antidepressant activity. In this work,...

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Published inResults in Chemistry Vol. 4; p. 100352
Main Authors Lata, Sneh, Dhir, Ashish, Kessar, S.V., Singh, K.N., Kulkarni, S.K., Singh, Pushpinder
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.01.2022
Elsevier
Subjects
Benzazepines
Cyclic ketones
Lithiation-substitution reactions
N-Methyl-1, 2, 3, 4-tetrahydroisoquinoline
Venlafaxine
Venlafaxine
N-Methyl-1, 2, 3, 4-tetrahydroisoquinoline
Benzazepines
Lithiation-substitution reactions
Cyclic ketones
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Summary:[Display omitted] The use of N-methyl-1, 2, 3, 4-tetrahydroisoquinoline as pharmacophores has been studied over the years. It has a structural similarity with the N, N-dimethyl phenethylamine, a framework entrenched in the drug venlafaxine, acknowledged for its antidepressant activity. In this work, the synthesis of β-substituted N-methyl-1, 2, 3, 4-tetrahydroisoquinolines and benzazepines was achieved and their application as potent monoamine reuptake inhibitors for neurological disorders was studied.
ISSN:2211-7156
2211-7156
DOI:10.1016/j.rechem.2022.100352