Interleukin-6 levels in relation with hormonal and metabolic profile in patients with polycystic ovary syndrome

• Published in: Gynecological endocrinology Vol. 30; no. 6; pp. 423 - 427
• Main Authors: Küçük, Mert, Alt nkaya, Sündüz Özlem, Nergiz, Sümeyra, Sezer, Selda Demircan, Yüksel, Hasan, Ba l, hsan, Y ld z, Gülserap
• Format: Journal Article
• Language: English
• Published: England Informa UK Ltd 01.06.2014; Taylor & Francis
• Subjects: Adolescent; Adult; Body Mass Index; Dehydroepiandrosterone Sulfate - blood; Female; Hirsutism - etiology; Humans; Hyperandrogenism - etiology; Hypertriglyceridemia - etiology; inflammation; Insulin Resistance; Interleukin-6; Interleukin-6 - blood; Lipoproteins, HDL - blood; Obesity - complications; Overweight - complications; polycystic ovary syndrome; Polycystic Ovary Syndrome - blood; Polycystic Ovary Syndrome - complications; Polycystic Ovary Syndrome - metabolism; Polycystic Ovary Syndrome - physiopathology; Prospective Studies; Severity of Illness Index; Testosterone - blood; Up-Regulation; Young Adult; inflammation; Interleukin-6; polycystic ovary syndrome
• ISSN: 0951-3590; 1473-0766
• DOI: 10.3109/09513590.2014.895981

Abstract Objective: The aim of this study was to evaluate serum concentrations of interleukin-6 (IL-6) in relation with hormonal and metabolic profile in patients with and without polycystic ovary syndrome (PCOS). Methods: A total of 40 women with PCOS and 40 age-matched controls were eligible for the study. Hirsutism scores, hormonal and metabolic profile as well as IL-6 levels were evaluated in each subject. Results: Women with PCOS exhibited higher body mass index (BMI) and serum concentrations of IL-6 levels than controls (p < 0.05); however, levels of IL-6 were not significantly increased when compared with BMI-matched controls (p > 0.05). IL-6 levels were significantly correlated positively with BMI and triglyceride levels; however, negatively correlated with high-density lipoprotein levels. Conclusion: The data of this study suggested that serum IL-6 levels were found to be higher in women with PCOS as compared to controls; however, IL-6 levels might be dependent on nutritional status but not on PCOS per se. Raised serum IL-6 levels may be related to BMI and serum lipid levels and may be a predictor for cardiometabolic risks.