Evaluation of microRNA-192 in patients with diabetic nephropathy
Background Diabetic nephropathy (DN) is the leading cause of kidney failure. The role of microRNAs (miRs) which are endogenous RNA oligonucleotides that regulate gene expression in DN is not yet clearly established. This study was designed to evaluate the blood level of miR-192 and its relation to d...
Saved in:
Published in | The Egyptian Journal of Internal Medicine Vol. 31; no. 2; pp. 122 - 128 |
---|---|
Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Berlin/Heidelberg
Springer Berlin Heidelberg
01.04.2019
Wolters Kluwer India Pvt. Ltd Medknow Publications and Media Pvt. Ltd Springer Nature B.V SpringerOpen |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Background
Diabetic nephropathy (DN) is the leading cause of kidney failure. The role of microRNAs (miRs) which are endogenous RNA oligonucleotides that regulate gene expression in DN is not yet clearly established. This study was designed to evaluate the blood level of miR-192 and its relation to disease severity in patients with type 2 diabetes mellitus with and without DN evidenced by the presence of albuminuria.
Materials and methods
The study included 60 patients (37 women and 23 men) with type 2 diabetes mellitus and 20 healthy control participants. All were subjected to thorough history taking, clinical evaluation and measurement of glycosylated hemoglobin, creatinine and urinary albumin/creatinine ratio. miR-192 was quantified in blood using reverse transcription TaqMan microRNA assay.
Results
The study showed that the miR-192 levels were significantly higher in patients with lower estimated glomerular filtration rate and higher albumin/creatinine ratio.
Conclusion
These findings may help to find a new marker for early detection of DN and this could be used in the future as a novel therapeutic target for the treatment of DN. |
---|---|
ISSN: | 1110-7782 2090-9098 |
DOI: | 10.4103/ejim.ejim_89_18 |