Estimating active bone marrow dose from occupational exposure to uranium at a former gaseous diffusion plant

Active bone marrow absorbed doses were estimated for 581 workers as part of a nested case-control study of multiple myeloma mortality at the Oak Ridge Gaseous Diffusion Plant (K-25). Uranium urinalysis results obtained by fluorometric and gross alpha measurements were available for about 20% of the...

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Bibliographic Details
Published inHealth physics (1958) Vol. 93; no. 2; p. 113
Main Authors Anderson, J L, Spitz, H B, Yiin, J H
Format Journal Article
LanguageEnglish
Published United States 01.08.2007
Subjects
Body Burden
Bone Marrow - chemistry
Bone Marrow - radiation effects
Humans
Occupational Exposure
Radiation Dosage
Uranium - analysis
Uranium - urine
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Summary:Active bone marrow absorbed doses were estimated for 581 workers as part of a nested case-control study of multiple myeloma mortality at the Oak Ridge Gaseous Diffusion Plant (K-25). Uranium urinalysis results obtained by fluorometric and gross alpha measurements were available for about 20% of the 581 study subjects. These data were used to determine intakes of uranium as a result of occupational exposure during operation of the K-25 facility. Uranium solubility was inferred from the observed urinary excretion rate, job titles, and department codes. Data suggest that most study subjects were exposed to uranyl fluoride, a relatively soluble uranium compound. The median cumulative bone marrow dose determined for subjects with bioassay data was 0.06 mGy with a geometric standard deviation of 4.48. Subjects without bioassay data were assigned cumulative bone marrow dose based upon job titles and department codes.
ISSN:0017-9078
DOI:10.1097/01.HP.0000261161.20101.36