Extracapsular invasion as a risk factor for disease recurrence in colorectal cancer

• Published in: World journal of gastroenterology : WJG Vol. 17; no. 15; pp. 2003 - 2006
• Main Authors: Fujii, Takaaki, Tabe, Yuichi, Yajima, Reina, Yamaguchi, Satoru, Tsutsumi, Soichi, Asao, Takayuki, Kuwano, Hiroyuki
• Format: Journal Article
• Language: English
• Published: United States Baishideng Publishing Group Co., Limited 21.04.2011
• Subjects: Aged; Aged, 80 and over; Brief; Colorectal Neoplasms - pathology; Colorectal Neoplasms - prevention & control; Colorectal Neoplasms - surgery; Disease-Free Survival; ECI; Female; Humans; Lymph Nodes - pathology; Lymphatic Metastasis - pathology; Male; Middle Aged; Multivariate Analysis; Neoplasm Staging; Recurrence; Retrospective Studies; Risk Factors; 入侵; 单因素分析; 危险因素; 复发间隔; 大肠癌; 淋巴结; 疾病; Extracapsular invasion; Metastasis; Lymph node; Adjuvant therapy; Colorectal cancer; Risk factor
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.v17.i15.2003

AIM： To evaluate the presence of extracapsular invasion （ECI） in positive nodes as a predictor of disease recurrence disease in colorectal cancer. METHODS： Two hundred and twenty-eight consecutive patients who underwent colorectal resection were identified for inclusion in this study, of which 46 had positive lymph nodes. Among 46 cases with stage Ⅲcolorectal cancer, 16 had ECI at positive nodes and 8 had disease recurrence. The clinical and pathological features of these cases were reviewed. RESULTS： In the univariate analysis, the number of positive lymph nodes and depth of tumor invasion were significantly associated with the presence of ECI at positive nodes. Multivariate analysis demonstrated that only ECI was a predictor of recurrence. The recurrence-free interval differed significantly among patients with ECI at positive nodes.CONCLUSION： Our results suggest that ECI at metastatic nodes can identify which cases are at high risk of short-term disease recurrence in colorectal cancer.